Lithosun is a brand of Lithium carbonate manufactured by Sun
Pharma India.
Lithium is an
essential medication in treating Bipolar Affective disorder. It is especially
effective in Manic phase of the illness. Numerous studies have shown its
effectiveness and no one doubts its effectiveness. However, it is a toxic
metallic ion that can be fatal if taken overdose.
Its toxic effects are thought to be mediated via Lithosun ‘s
ability to interfere with Sodium potassium channels in neurons. In a normal
neuronal cell, there is an electrical gradient between outer and inner cell
membranes. This electrical gradient is essential for neuronal transmission.
Problem with Lithium is Human body mistakenly thinks Lithium is sodium and incorporate
it instead of Sodium in the ion channels. This disrupts cell membrane
electrical gradient and disrupt neuronal transmission. However, this effect is
marked only in over dose.
Normally Lithosun is toxic when the plasma levels go beyond
1.2 mmol/l. Problem is that lithium need to be given dose above 0.6 mmol/l to
be effective. Therefore, Lithosun level should be maintained within a very
narrow spectrum. Therefore, patients who are on lithium should follow strict
guidelines on how to maintain lithium levels at optimal level.
Generally following advices should be followed to avoid Lithosun
toxicity,
1.
Take adequate water.
2.
When going to a doctor for any other illness, patients
need to tell him/her that they are taking lithium as some medications can cause
dangerous interactions with Lithium
3.
In addition, they should know toxic side effects
of Lithium such as Gross tremors of limbs, severe vomiting, diarrhea, and
confusion.
4.
Check blood lithium levels at least three
monthly intervals. However, in some centers Blood lithium level test can be an
expensive one.
Another interesting
finding is before 1951 Lithium is included in popular soft drink 7Up. It was introduced
to improve mood. After that it was discontinued due to reports of toxicity.
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