Clofranil is a brand of Clomipramine. It is prescribed for obsessive
compulsive disorder and depressive disorder. Main side effects are drowsiness, feeling
faintish, dry mouth and constipation. This is a TCA class antidepressant with
more serotonergic actions than other TCA antidepressants. More serotonergic
action makes this medication more similar to SSRI (Selective serotonin reuptake
inhibitors) class medication and it is more effective in OCD (Obsessive
compulsive disorder).
Clofranil 50mg tablets |
Uses of Clofranil
This medication is an antidepressant. It is primarily used
for mental health problems such as depression and obsessive compulsive
disorder. Compared to other antidepressants in this class, this medication is
more effective in OCD or obsessive compulsive disorder.
This medication is useful in treating OCD (Obsessive compulsive disorder) |
Obsessive compulsive disorder is a mental health problem
associated with repeated thoughts or actions that are resisted. A common example is excessive hand washing in
a patient with repetitive belief that his/her hands are contaminated by germs.
Usually excessive means around more than 10 times of washing hands per session.
Usually the compulsion or act starts once the patient gets the thought that his
hands are dirty.
In fact, in current psychiatry practice it is used as a
medication for OCD than depression. Most doctors use it as a second line
treatment option for OCD, due to its unfavorable side effects profile. But
according to this author's experience this medication helps patients who are
resistant to SSRI medications.
What are the common side effects of Clofranil?
- Drowsiness
- Dry mouth
- Constipation
- Increased heart rate
- Feeling faintish
- Confusion
- Nausea
- Headache
- Yawning
- Blurred vision
- Sexual dysfunction
Since this is a TCA (Tricyclic antidepressant) class
medication, drowsiness and dry mouth is common. Usually SSRI medications do not
cause such side effects.
Due to side effect of drowsiness, it will affect driving and
ability to operate machinery.
Sexual dysfunction includes erectile dysfunction in males
and reduced sexual desire in females.
What are the dangerous side effects?
- Urine retention
- Glaucoma or increased eye pressure
- Heart block
- Mania
Since this medication can cause serious heart problems
(heart block) it is toxic when taken overdose. Therefore, it is prescribed
carefully for highly suicidal patients. This medication can cause manic shift
in patients with bipolar affective disorder. Urine retention can be a troublesome
side effect in elderly patients.
What are rare but documented side effects of Clofranil?
- Breast enlargement
- Increased appetite with increased body weight
- Getting low sodium in the blood (Hyponatremia)
- Hallucinations
- Epileptic Seizures
- Flushing
- Impaired memory
- Muscle weakness
Things you need to discuss with your doctor?
Before getting the prescription, you need to inform your
doctor if you have following medical/psychiatric conditions.
- Any heart disease or Hypertension
- Liver disease
- Kidney disease
- Bipolar affective disorder
- Diabetes mellitus
- Schizophrenia
- Eye problems
- Prostate problems in males (History of urinary retention)
- Long standing constipation
- History of all the medications you are on including street drugs
Compared to newer anti-depressants this medication is safe
in pregnancy and breast feeding. It is due to availability of large amount of
safety information.
How Clofranil is taken?
This medication is available as 50mg and 25mg tablets. Usual dose range
is 50mg per day to 250mg per day. It should be taken with a full glass of water
and should not be crushed before ingesting.
Summary
Clofranil is a TCA class antidepressant medication usually
prescribed for OCD (Obsessive compulsive disorder) and depression. Common side
effects are drowsiness and dry mouth.
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