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Thursday, November 3, 2011

Use and side effects of Arima (Moclobemide)

Arima is a brand name of Moclobemide. It is prescribed for depression and social anxiety disorder. It acts via inhibiting Mono amine oxidase enzyme present in certain areas of the body. This causes accumulation of mono amines (serotonin, Noradrenealin and dopamine). Increased levels of above mono amines results in neuronal changes that ultimately treats depression and social anxiety disorder.


Common side effects of Arima (Moclobemide)

1. Insomnia, dizziness, agitation, anxiety, restlessness

2. Dry mouth, diarrhea, constipation, nausea, vomiting

3. Abnormal milk secretion from the breasts

4. Rarely hypertension

Dangerous side effects

1. Hypertensive crisis (especially when Arima is used with certain tyramine containing foods (Cheese and wine) - risk is less compared to irreversible MAOIs such as Phenelzine (Nardil))

2. Induction of mania in susceptible people (patients with underlying bipolar disorder)

3. Rarely activation of suicidal ideation and behavior (suicidality)

4. Seizures or fits

Weight gain and sedation are minimal with Ariima (Moclobemide)

Trazadone can be used in Arima (Moclobemide) induced insomnia.

First published in
Mental health information blog

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